A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity

نویسندگان

چکیده

The amanitins (namely ?- and ?-amanitin) contained in certain mushrooms are bicyclic octapeptides that, when ingested, responsible for potentially lethal hepatotoxicity. M101 is an extracellular hemoglobin extracted from the marine worm Arenicola marina . It has intrinsic Cu/Zn-SOD-like activity currently used as oxygen carrier organ preservation solutions. Our present results suggest that might be effective reducing amanitin-induced hepatotoxicity may have potential therapeutic development. • ?-amanitin lead to cell death mitochondrial reactive species production differentiated HepaRG cells. vitro.

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ژورنال

عنوان ژورنال: Toxicon

سال: 2021

ISSN: ['0041-0101', '1879-3150']

DOI: https://doi.org/10.1016/j.toxicon.2021.07.004