A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity
نویسندگان
چکیده
The amanitins (namely ?- and ?-amanitin) contained in certain mushrooms are bicyclic octapeptides that, when ingested, responsible for potentially lethal hepatotoxicity. M101 is an extracellular hemoglobin extracted from the marine worm Arenicola marina . It has intrinsic Cu/Zn-SOD-like activity currently used as oxygen carrier organ preservation solutions. Our present results suggest that might be effective reducing amanitin-induced hepatotoxicity may have potential therapeutic development. • ?-amanitin lead to cell death mitochondrial reactive species production differentiated HepaRG cells. vitro.
منابع مشابه
Arenicola marina extracellular hemoglobin: a new promising blood substitute.
The need to develop a blood substitute is now urgent because of the increasing concern over Europe's BSE outbreak and the worldwide HIV/AIDS epidemic, which have cut blood supplies. Extracellular soluble hemoglobin has long been studied for its possible use as a safe and effective alternative to blood transfusion, but this has met with little success. Clinical trials have revealed undesirable s...
متن کاملObservations on the burrowing of Arenicola marina (L.).
The hydrostatic skeleton of Arenicola marina has been investigated in some detail both by Chapman & Newell (1947) and by Wells (1954) and our knowledge of the habits of this species is broadly based on the extensive researches of the latter author (1961). When a new method of continuous pressure recording became available to me I immediately tried it out on Arenicola as an established standard ...
متن کاملArenicolid behaviors: similarity of Arenicola marina and Abarenicola pacifica
The hydraulic activities of two arenicolid polychaetes, Abarenicola pacifica and Arenicola marina, result in strikingly similar pressure waveforms. The principal hydraulic activities are defecation, burrowing and feeding/ burrow maintenance. Both the duration and magnitudes of the pressures are very similar. The behavioral periodicities of the two species are also quite similar, although burrow...
متن کاملLuteimonas marina sp. nov., isolated from seawater.
A marine bacterial strain, designated FR1330(T), was isolated from a seawater sample collected near Ganghwa Island, the Republic of Korea. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain FR1330(T) belonged to the Gammaproteobacteria and was related to the genus Luteimonas; its closest neighbours were the type strains of Luteimonas composti (97.9 % sequence similarit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxicon
سال: 2021
ISSN: ['0041-0101', '1879-3150']
DOI: https://doi.org/10.1016/j.toxicon.2021.07.004